There are many different glomerular disorders, including glomerulonephritis, diabetic
nephropathy, and hypertensive nephrosclerosis. However, once glomerular damage …

Many clinical observations suggest common mediators in the progression of kidney disease
leading to eventual kidney failure. Among them, accumulating evidence emphasizes the role …

Tubulointerstitial damage and progression of renal failure. The present work reviews the
mechanisms and close association between glomerular and tubular damage and its …

Chronic proteinuric renal diseases, independent from the type of the initial insult, have in
common a loss of selectivity of the glomerular barrier to protein filtration. Glomerular …

Tubulointerstitial injury is an invariant finding in the chronically diseased kidney, irrespective
of the type of disease or the compartment in which the disease originates. Such histologic …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

In chronic kidney disease (CKD), once injury from any number of disease processes
reaches a threshold, there follows an apparently irreversible course toward decline in kidney …

Recent studies emphasize the role of chronic hypoxia in the tubulointerstitium as a final
common pathway to end-stage renal failure. When advanced, tubulointerstitial damage is …

Progressive renal failure results from a triad of glomerulosclerosis, tubulointerstitial fibrosis
and vascular sclerosis. The mechanisms by which tubules are injured, and by which the …

Accumulating evidence suggests that the central locus for the progression of CKD is the
renal proximal tubule. As injured tubular epithelial cells dedifferentiate in attempted repair …