The antioxidant response element (ARE) mediates the transcriptional activation of many
genes encoding phase II drug-metabolizing enzymes in response to oxidative stress. Recent …

Nrf2 accumulates in nuclei upon exposure to oxidative stress, heterodimerizes with a small
Maf protein, and activates the transcription of stress target genes through antioxidant …

The induction of many antioxidant and phase II drug-metabolizing enzymes by phenolic
antioxidants and electrophilic compounds is regulated at the transcriptional level. The …

Nrf2 (NF-E2-related factor 2) is a central transcription factor involved in the transcriptional
activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant …

A central mechanism in cellular defence against oxidative or electrophilic stress is mediated
by transcriptional induction of genes via the ARE (antioxidant-response element), a cis …

The expression of genes encoding antioxidative and Phase II detoxification enzymes is
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …

The induction of phase II detoxifying enzymes is an important defense mechanism against
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …

Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …

An antioxidant responsive element (ARE) or electrophile responsive element (EpRE)
mediates the transcriptional activation of genes encoding phase II drug metabolizing …

Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that
commonly contains a unique basic-leucine zipper domain. Among CNC family members …