Phospholipid scramblases: an overview

SK Sahu, SN Gummadi, N Manoj… - Archives of biochemistry …, 2007 - Elsevier
Phospholipid scramblases are a group of homologous proteins that are conserved in all
eukaryotic organisms. They are believed to be involved in destroying plasma membrane …

Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane

T Wiedmer, J Zhao, M Nanjundan, PJ Sims - Biochemistry, 2003 - ACS Publications
Phospholipid scramblase 1 (PLSCR1) is a Ca2+-binding, endofacial plasma membrane
protein thought to contribute to the transbilayer movement of phosphatidylserine and other …

[HTML][HTML] Identification of three new members of the phospholipid scramblase gene family

T Wiedmer, Q Zhou, DY Kwoh, PJ Sims - Biochimica et Biophysica Acta …, 2000 - Elsevier
Phospholipid (PL) scramblase is a 35 kDa protein that is thought to mediate Ca2+-induced
bidirectional transbilayer movement of plasma membrane phospholipids in activated …

Phospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors

J Dal Col, MJ Lamberti, A Nigro, V Casolaro… - Cell Communication and …, 2022 - Springer
Abstract Phospholipid scramblase 1 (PLSCR1) is the most studied protein of the scramblase
family. Originally, it was identified as a membrane protein involved in maintaining plasma …

Unraveling the mysteries of phospholipid scrambling

PJ Sims, T Wiedmer - Thrombosis and haemostasis, 2001 - thieme-connect.com
Plasma membrane phospholipid asymmetry is maintained by an aminophospholipid
translocase that transports phosphatidylserine (PS) and phosphatidylethanolamine (PE) …

Phospholipid scramblase 1 binds to the promoter region of the inositol 1, 4, 5-triphosphate receptor type 1 gene to enhance its expression

Q Zhou, I Ben-Efraim, JL Bigcas, D Junqueira… - Journal of Biological …, 2005 - ASBMB
Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated, endofacial membrane
protein originally identified based on its capacity to promote accelerated transbilayer …

Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1

Q Zhou, J Zhao, T Wiedmer… - Blood, The Journal of the …, 2002 - ashpublications.org
Phospholipid scramblase 1 (PLSCR1) is an endofacial plasma membrane protein proposed
to participate in transbilayer movement of phosphatidylserine and other phospholipids. In …

Phospholipid Scramblase 1 Is Imported into the Nucleus by a Receptor-Mediated Pathway and Interacts with DNA,

I Ben-Efraim, Q Zhou, T Wiedmer, L Gerace… - Biochemistry, 2004 - ACS Publications
Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated, Ca2+-binding, endofacial
plasma membrane protein originally identified by its capacity to accelerate transbilayer …

Phospholipid scramblase 1 potentiates the antiviral activity of interferon

B Dong, Q Zhou, J Zhao, A Zhou, RN Harty… - Journal of …, 2004 - Am Soc Microbiol
ABSTRACT Phospholipid scramblase 1 (PLSCR1) is an interferon (IFN)-and growth factor-
inducible, calcium-binding protein that either inserts into the plasma membrane or binds …

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cδ

SC Frasch, PM Henson, JM Kailey, DA Richter… - Journal of Biological …, 2000 - ASBMB
Phospholipid scramblase induces nonspecific bidirectional movement of phospholipids
across the membrane during cell activation and has been proposed to mediate the …