It is a great honour to give the Eighteenth Hopkins Memorial Lecture, and to join the
distinguished list of past recipients of this medal. In particular, it gives me much pleasure to …

There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

Summary Protein Ser, Thr and Tyr kinases play essential roles in signal transduction in
organisms ranging from yeast to mammals, where they regulate a variety of cellular …

Tyrosine phosphorylation of proteins was discovered 10 years ago. This anniversary is an
appropriate time to review briefly what we have learned in that time. The field has grown …

Protein-tyrosine phosphorylation has long been regarded as an exclusively eukaryotic
phenomenon. Although some non-eukaryotes, mainly viruses, possess genes encoding …

898 HUNTER & COOPER cleotides had set a precedent, reports of orthophosphate
esterified to tyrosine did not emerge until 1979 (1). Phosphotyrosine (P. Tyr) was first …

Tyrosine kinases, enzymes that catalyze the transfer of phosphate from ATP to tyrosine
residues in polypeptides, are ubiquitous, numerous, and of considerable clinical interest …

Unrestricted protein tyrosine phosphatase (PTPase) activity may play a role in pathogenesis.
For instance, the virulence determinant gene, yopH, of Yersinia pseudotuberculosis …

Protein phosphorylation has been shown to occur in over fifty different bacterial species and,
therefore, seems to be a universal device among prokaryotes. Most of the protein kinases …

Protein kinases play central roles in the regulation of eukaryotic and prokaryotic cell growth,
division, and differentiation. The Caulobacter crescentus divL gene encodes a novel …