In the 30 years since its discovery, tyrosine phosphorylation has emerged as a
fundamentally important mechanism of signal transduction and regulation in all eukaryotic …

p-Carboxymethyl-l-phenylalanine (p CMF), a phosphotyrosine (pTyr) mimetic that is resistant
to protein tyrosine phosphatase hydrolysis, was cotranslationally incorporated into proteins …

Protein phosphorylation on serine, threonine, and tyrosine (Ser/Thr/Tyr) is well established
as a key regulatory posttranslational modification in eukaryotes, but little is known about its …

The phosphorylation on tyrosine of a protein in Escherichia coli both in vivo and in vitro was
revealed by recognition by anti-phosphotyrosine antibodies, labelling with [γ-32P] ATP, and …

62 Hunter T: Tyrosine phosphorylation in signaling and disease kinases and 90 tyrosine
kinases. And among the 90 tyrosine kinases, 58 are receptor tyrosine kinases and 32 are …

Autophosphorylating histidine kinase and response-regulator domains constitute the
building blocks of two-component signaling systems. These systems use a unique …

Phosphagen kinases are found throughout the animal kingdom and catalyze the transfer of
a high-energy gamma phosphoryl-group from ATP to a guanidino group on a suitable …

Phosphate ester formation and hydrolysis are likely the most crucial chemical reactions
carried out by living organisms. Polymerization of the genetic material involves these …

Screening of a human embryonic lung fibroblast cDNA expression library with
antiphosphotyrosine antibodies led to isolation of a novel protein kinase. A clone …

Publisher Summary It is important to realize that in vivo protein tyrosine phosphorylation is a
reversible, dynamic process in which the net level of phosphate in a target substrate reflects …