Introduction Interest in sigma-1 receptors (S1Rs) has significantly increased in the last 25
years and more recently for their role in pain modulation. S1Rs are novel chaperone …

Introduction: The sigma-1 receptor (σ1R) is a ligand-regulated molecular chaperone that
interacts with other proteins, including NMDA and opioid receptors, to modulate their activity …

The sigma-1 receptor (σ1R) is located in areas of the CNS key for pain control and belongs
to a unique target class with chaperoning functions over different molecular targets involved …

Sigma receptors modulate nociception, offering a potential therapeutic target to treat pain,
but relatively little is known regarding the role of sigma-2 receptors (S2R) in nociception. The …

Abstract Sigma 1 receptor (σ 1 receptor) is a unique ligand-regulated molecular chaperone
located mainly in the endoplasmic reticulum and the plasma membrane. σ 1 receptor is …

Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without
the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of …

Sigma-1 receptors (S1Rs) are strongly correlated to neuropathic pain (NP), since their
inactivation may decrease allodynia or dysesthesia, promoting analgesic effects. In the …

Neuropathic pain (NP) is a chronic condition resulting from damaged pain-signaling
pathways. It is a debilitating disorder that affects up to 10% of the world's population …

There is a critical need for new analgesics acting through new mechanisms of action, which
could increase the efficacy with respect to existing therapies and reduce their unwanted …

Sigma receptors are protein chaperones with the unexpected characteristic of being
activated by ligand binding. As such, they represent intriguing new targets for potential drug …