Successful T cell activation via the T cell receptor (TCR)/CD3 complex requires at least one
contact-dependent second signal delivered by costimulatory molecules, including the …

Defective T cell functions, including IL‐2 production and proliferation, have been shown in
SLE patients. After T cell stimulation (first signal), a costimulatory signal (second signal) is …

The activation of T lymphocytes requires both Ag-mediated signaling through the TCR as
well as costimulatory signals transmitted through B7-1 and/or B7-2 with CD28. The …

The CD28/CTLA4-B7-family plays an important role in T-cell costimulation and is crucial for
IL-2 production and tolerance induction. The costimulatory molecule B7-BB1 (CD80) is …

The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen
presenting cells plays an important role in a broad range of functions of the immune system …

Objective. To examine the expression of costimulatory molecules of the B7 and CD28
receptor families in active skin lesions of patients with systemic lupus erythematosus (SLE) …

Abstract B7/CD28-mediated costimulation is a promising target for therapeutic intervention
in autoimmune diseases. However, studies addressing the differential functional roles of B7 …

B cells in patients with systemic lupus erythematosus (SLE) are hyperactivated and B-cell
receptor signal transduction may be affected by various response regulators. CD19 and …

Cognate interactions between major histocompatibility complex class II antigen (Ag)‐
reactive CD4+ T helper (Th) and Ag‐presenting B cells induce first the activation of B cells …

B7/BB1 is a physiological ligand for CD28, a receptor expressed on a major subset of T
lymphocytes. B7/BB1 has been shown to be expressed on human blood dendritic cells and …