Dual roles of HK3 in regulating the network between tumor cells and tumor-associated macrophages in neuroblastoma
X Wu, T Mi, L Jin, C Ren, J Wang, Z Zhang, J Liu… - Cancer Immunology …, 2024 - Springer
Neuroblastoma (NB) is the most common and deadliest extracranial solid tumor in children.
Targeting tumor-associated macrophages (TAMs) is a strategy for attenuating tumor …
Targeting tumor-associated macrophages (TAMs) is a strategy for attenuating tumor …
HK3 stimulates immune cell infiltration to promote glioma deterioration
S Li, Z Li, X Wang, J Zhong, D Yu, H Chen, W Ma… - Cancer Cell …, 2023 - Springer
Background Glioma is the most common and lethal type of brain tumor, and it is
characterized by unfavorable prognosis and high recurrence rates. The reprogramming of …
characterized by unfavorable prognosis and high recurrence rates. The reprogramming of …
Exploring the prognostic value of HK3 and its association with immune infiltration in glioblastoma multiforme
Y Yang, X Fu, R Liu, L Yan, Y Yang - Frontiers in Genetics, 2023 - frontiersin.org
Background: Hexokinase 3 (HK3) is one of the key enzymes involved in glucose
phosphorylation (the first step in most glucose metabolic pathways). Many studies have …
phosphorylation (the first step in most glucose metabolic pathways). Many studies have …
The expression of Hexokinase 2 and its hub genes are correlated with the prognosis in glioma
Y Huang, F Ouyang, F Yang, N Zhang, W Zhao, H Xu… - BMC cancer, 2022 - Springer
Abstract Background Hexokinase 2 (HK2) is an enzyme that catalyses the conversion of
glucose to glucose-6-phosphate, which has been found to be associated with malignant …
glucose to glucose-6-phosphate, which has been found to be associated with malignant …
Glioma hexokinase 3 positively correlates with malignancy and macrophage infiltration
T Liang, X Zhou, Y Wang, W Ma - Metabolic Brain Disease, 2024 - Springer
Background Glioma is the main subtype of primary central nervous system (CNS) tumor with
high malignancy and poor prognosis under current therapeutic approaches. Glycolysis and …
high malignancy and poor prognosis under current therapeutic approaches. Glycolysis and …
HK2 contributes to the proliferation, migration, and invasion of diffuse large B-cell lymphoma cells by enhancing the ERK1/2 signaling pathway
H Zhao, G Xiang, T Shao, M Wang, W Dai - Open Life Sciences, 2023 - degruyter.com
Abstract Hexokinase 2 (HK2) has been associated with carcinogenic growth in numerous
kinds of malignancies as essential regulators during the processing of glucose. This study …
kinds of malignancies as essential regulators during the processing of glucose. This study …
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
MC Takenaka, G Gabriely, V Rothhammer… - Nature …, 2019 - nature.com
Tumor-associated macrophages (TAMs) play an important role in the immune response to
cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell …
cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell …
Kill and Clearance in HCC: an approach based on NK cells and macrophages
M Mehrabi, F Amini, S Mehrabi - Frontiers in Oncology, 2021 - frontiersin.org
In our previous perspective, we investigated the role of hypoxic lesions in the development
of necrotic zone in solid tumors (1). We suggested the increased infiltration of macrophages …
of necrotic zone in solid tumors (1). We suggested the increased infiltration of macrophages …
High levels of HIST1H2BK in low-grade glioma predicts poor prognosis: a study using CGGA and TCGA data
W Liu, Z Xu, J Zhou, S Xing, Z Li, X Gao, S Feng… - Frontiers in …, 2020 - frontiersin.org
A number of biomarkers have been identified for various cancers. However, biomarkers
associated with glioma remain largely to be explored. In the current study, we investigated …
associated with glioma remain largely to be explored. In the current study, we investigated …
MKK7 transcription positively or negatively regulated by SP1 and KLF5 depends on HDAC4 activity in glioma
Y Wang, Y Xia, K Hu, M Zeng, C Zhi… - … journal of cancer, 2019 - Wiley Online Library
JNK activity has been implicated in the malignant proliferation, invasion and drug‐resistance
of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently …
of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently …