Background Inappropriate polypharmacy is a particular concern in older people and is
associated with negative health outcomes. Choosing the best interventions to improve …

Objective To summarise the findings of an updated Cochrane review of interventions aimed
at improving the appropriate use of polypharmacy in older people. Design Cochrane …

Background: Polypharmacy paves the way for non-adherence, adverse drug reactions,
negative health outcomes, increased use of healthcare services and rising costs. Since it is …

Objective Polypharmacy is widespread among older people, but the adverse outcomes
associated with it are unclear. We aim to synthesize current evidence on the adverse health …

OBJECTIVES To develop a core outcome set (COS) for use in effectiveness trials of
interventions aiming to improve the appropriateness of polypharmacy in older people in …

Background Multimorbidity is increasing in aging populations with a corresponding increase
in polypharmacy as well as inappropriate prescribing. Depending on definitions, 25-50% of …

Introduction: Single disease state led evidence-based guidelines do not provide sufficient
coverage of issues of multimorbidities, with the cumulative impact of recommendations often …

Polypharmacy in the elderly complicates therapy, increases cost, and is a challenge for
healthcare agencies. In the context of the evolving role of the pharmacist, this systematic …

Globally, the number of drug prescriptions is increasing causing more adverse drug events,
which is now a significant cause of mortality, morbidity, and disability that has reached …

There are many challenges to ensuring good outcomes from the pharmacologic
management of older adults. With advancing age, the increased prevalence of diseases …