The pathogenesis of osteoarthritis involves multiple etiologies, including mechanical,
biochemical, and genetic factors that contribute to the imbalance in the synthesis and …

Studies in animal models of osteoarthritis (OA) have been used extensively to gain insight
into the pathogenesis of OA, but early studies largely ignored inflammation except as a …

The putative role and mechanism of action of cytokines in the progression of arthritic
diseases such as osteoarthritis (OA) has received particular attention because of the …

OBJECTIVE:: The integrity of articular cartilage is maintained by the balance between
cytokine-driven anabolic and catabolic processes. Unregulated or excess influences of …

Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

Connective tissue is characterized by its abundant extracellular matrix, whose structure
plays an integral role in tissue function. Matrix homeostasis is principally controlled by …

[Frontiers in Bioscience 4, d694-703, October 15, 1999] 694 CYTOKINES AND THEIR ROLE IN
THE PATHOPHYSIOLOGY OF OSTEOARTHRITIS Jo Page 1 [Frontiers in Bioscience 4 …

Morphological changes observed in OA include cartilage erosion as well as a variable
degree of synovial inflammation. Current research attributes these changes to a complex …

Chondrocytes are the single cellular component of hyaline cartilage. Under physiologic
conditions, they show steady-state equilibrium between anabolic and catabolic activities that …

Several recent in vitro investigations and experimental studies performed in animal models
of osteoarthritis (OA) sustained the previously held view that interleukin (IL)-1 or tumour …