Renal ischemia/reperfusion (I/R) injury continues to be a complicated situation in clinical
practice. Genistein, the main isoflavone found in soy products, is known to possess a wide …

Diabetic nephropathy (DN) as a global health concern is closely related to inflammation and
oxidation. Isoliquiritigenin (ISL), a natural flavonoid compound, has been demonstrated to …

Abstract Sirtuin1 (SIRT1), a class III histone deacetylase, exerts a protective role against
kidney injury. However, its functions in renal ischemia/reperfusion (I/R) injury remains …

Abstract Background Sirtuin 3 (Sirt3) is a key regulator of energy metabolism and oxidative
stress. To investigate the role of Sirt3 in contrast-induced acute kidney injury (CIAKI), we …

Sirtuin 1 (Sirt1) is an essential modulator of cellular metabolism and has pleiotropic effects. It
was recently reported that Sirt1 overexpression in kidney tubule ameliorates cisplatin …

Background This study determined the possible anti-inflammatory and antioxidant renal
protective effect of genistein, a soy isoflavone, against kidney damage and functional …

Oxidative stress is a key component of renal ischemia/reperfusion (I/R) injury. Fucoxanthin
(Fx), a marine carotenoid with enhanced antioxidant capacity, acts as a ROS inhibitor in …

Acute kidney injury (AKI) is a public health problem worldwide. Sirtuins are a family of seven
NAD+-dependent deacylases, Overexpression of Sirtuin 1, 3, and 5 protect against AKI …

Sepsis often results in damage to multiple organ systems, possibly due to severe
mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been …

Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). Our
previous studies have shown that the total flavonoids (TFs) from Rosa laevigata Michx fruit …