Hormonal regulation of prostaglandin E2 receptors: localization and expression in rat cervical tissue

AC Hinton, PL Grigsby, BA Pitzer… - Reproductive …, 2010 - journals.sagepub.com
Prostaglandin E2 (PGE2) may regulate uterine activation and cervical ripening for labor
through specific contractile and relaxatory receptors (EP1-4). The aim of this study was to …

Localization and expression of prostaglandin E2 receptors in human placenta and corresponding fetal membranes with labor

PL Grigsby, SR Sooranna, DE Brockman… - American journal of …, 2006 - Elsevier
OBJECTIVE: The effects of prostaglandin E2 (PGE2) are mediated through G-protein
coupled receptors, acting via different second messengers. The aim of this study was to …

The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility

S Arulkumaran, MK Kandola, B Hoffman… - The Journal of …, 2012 - academic.oup.com
Context: Prostaglandins are central to the processes of human labor. Prostaglandin E2
(PGE2) synthesized within the uterus mediates cervical ripening and uterine contractions …

Distribution and function of prostaglandin E2 receptors in mouse uterus: translational value for human reproduction

DP Fischer, AL Griffiths, S Lui, UJ Sabar, D Farrar… - … of Pharmacology and …, 2020 - ASPET
Prostaglandin (PG) E analogs are used clinically to ripen the cervix and induce labor.
However, selective receptor agonists may have potential to improve induction response …

Identification and localization of prostaglandin E2 receptors in upper and lower segment human myometrium during pregnancy

S Astle, S Thornton, DM Slater - Molecular Human Reproduction, 2005 - academic.oup.com
Abstract Prostaglandin E2 (PGE2) plays a key role in the maintenance of human pregnancy
and labour onset. PGE2 can elicit diverse actions within the uterus depending on the PGE2 …

Expression and regulation of the rat prostaglandin E2 receptor type 4 (EP4) in pregnant cervical tissue

EK Chien, C MacGregor - American journal of obstetrics and gynecology, 2003 - Elsevier
OBJECTIVE: Prostaglandins play an important role in the regulation of parturition and
cervical ripening. Prostaglandin E2 (PGE2)–induced tissue remodeling is mediated through …

Effects of gestational age on prostaglandin EP receptor expression and functional involvement during in vitro contraction of the guinea pig uterus

KK Terry, WS Lebel, KA Riccardi, WA Grasser… - … and essential fatty acids, 2008 - Elsevier
Prostaglandin E2 (PGE2) exerts diverse biological effects through four G-protein-coupled
cell surface receptor subtypes, EP1–4. This study's objective was to characterize EP1–4 …

'Distinct Cellular Localization of the Messenger Ribonucleic Acid for Prostaglandin E Receptor Subtypes in the Mouse Uterus during Pseudopregnancy

M Katsuyama, Y Sugimoto, K Morimoto… - …, 1997 - academic.oup.com
As an initial step to clarify the mechanisms of various uterine actions of PGE2, expression
patterns of the messenger RNAs (mRNAs) for four subtypes of PGE receptors, EP1, EP2 …

Characterization of Temporal and Cell-Specific Changes in Transcripts for Prostaglandin E2 Receptors in Pseudopregnant Rat Endometrium

KD Papay, TG Kennedy - Biology of reproduction, 2000 - academic.oup.com
In the rodent uterus, prostaglandin E2 (PGE2) is believed to have a major role in
implantation and decidualization. The present study investigated the temporal and hormonal …

The expression of prostaglandin receptors EP 3 and EP 4 in human cervix in post‐term pregnancy differs between failed and successful labor induction

N Roos, CS Blesson, O Stephansson… - Acta obstetricia et …, 2014 - Wiley Online Library
Objective To investigate expression and localization of prostaglandin receptors EP 1‐4 and
FP and localization of stromal factors CTGF (connective tissue growth factor), furin …