An Erlotinib gold (I) conjugate for combating triple-negative breast cancer
An Erlotinib triphenylphosphane gold (I) conjugate has been prepared from AuCl (PPh 3)
and its crystal structure has been established by X-ray diffraction, showing a metallo-helicate …
and its crystal structure has been established by X-ray diffraction, showing a metallo-helicate …
[HTML][HTML] Gold derivatives development as prospective anticancer drugs for breast cancer treatment
Commonly used anticancer drugs are cis platin and other platinum-based drugs. However,
the use of these drugs in chemotherapy causes numerous side effects and the onset of …
the use of these drugs in chemotherapy causes numerous side effects and the onset of …
[HTML][HTML] Multi-targeted anticancer activity of imidazolate phosphane gold (I) compounds by inhibition of DHFR and TrxR in breast cancer cells
A class of phosphane gold (I) compounds, made of azoles and phosphane ligands, was
evaluated for a screening on the regards of Breast Cancer cell panels (BC). The compounds …
evaluated for a screening on the regards of Breast Cancer cell panels (BC). The compounds …
Synthesis, properties, and antitumor effects of a new mixed phosphine gold (I) compound in human colon cancer cells
G Lupidi, L Avenali, M Bramucci, L Quassinti… - Journal of Inorganic …, 2013 - Elsevier
The antineoplastic potential of a new stable mixed phosphine gold (I) complex containing
tris (tert-butyl) phosphine (tBu3P) and bis (diphenylphosphino) ethene (dppet), namely [Au …
tris (tert-butyl) phosphine (tBu3P) and bis (diphenylphosphino) ethene (dppet), namely [Au …
Bioactive gold (I) complexes with 4-mercaptoproline derivatives
A Gutiérrez, C Cativiela, A Laguna, MC Gimeno - Dalton Transactions, 2016 - pubs.rsc.org
Unprecedented gold (I) bioconjugates bearing non-proteinogenic amino acid 4-
mercaptoproline species as bioorganic ligands have been prepared. Firstly, the synthesis of …
mercaptoproline species as bioorganic ligands have been prepared. Firstly, the synthesis of …
Synthesis, characterization and anticancer activity of gold (I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands
M Altaf, M Monim-ul-Mehboob, AAA Seliman… - European Journal of …, 2015 - Elsevier
Two new gold (I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate
ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic …
ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic …
[HTML][HTML] Breast Cancer Treatment: The Case of Gold (I)-Based Compounds as a Promising Class of Bioactive Molecules
Breast cancers (BCs) may present dramatic diagnoses, both for ineffective therapies and for
the limited outcomes in terms of lifespan. For these types of tumors, the search for new drugs …
the limited outcomes in terms of lifespan. For these types of tumors, the search for new drugs …
Linear gold (I) complex with tris-(2-carboxyethyl) phosphine (TCEP): Selective antitumor activity and inertness toward sulfur proteins
The search for modulating ligand substitution reaction in gold complexes is essential to find
new active metallo compounds for medical applications. In this work, a new linear and …
new active metallo compounds for medical applications. In this work, a new linear and …
On the medicinal chemistry of gold complexes as anticancer drugs
I Ott - Coordination Chemistry Reviews, 2009 - Elsevier
Metal complexes have shown interesting preclinical and clinical results as antitumor drugs
and platinum compounds are well established in current cancer chemotherapy. However …
and platinum compounds are well established in current cancer chemotherapy. However …
[HTML][HTML] Gold (I/III)-phosphine complexes as potent antiproliferative agents
The reaction of gold reagents [HAuCl4• 3H2O],[AuCl (tht)], or cyclometalated gold (III)
precursor,[C^ NAuCl2] with chiral ((R, R)-(-)-2, 3-bis (t-butylmethylphosphino) quinoxaline) …
precursor,[C^ NAuCl2] with chiral ((R, R)-(-)-2, 3-bis (t-butylmethylphosphino) quinoxaline) …