Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …

Cellular senescence is a major contributor to age-related diseases in humans; however, it
also has a beneficial role in physiological and pathological processes, including wound …

Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …

Senescent cells accumulate with aging and at etiological sites of multiple diseases,
including those accounting for most morbidity, mortality, and health costs. Senescent cells …

Aging is the major predictor for developing multiple neurodegenerative diseases, including
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …

Aging is a physiological decline in both structural homeostasis and functional integrity,
progressively affecting organismal health. A major hallmark of aging is the accumulation of …

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …