Cellular senescence and senolytics: the path to the clinic
S Chaib, T Tchkonia, JL Kirkland - Nature medicine, 2022 - nature.com
Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …
disorders and diseases. One such process is cellular senescence, which entails a state of …
Targeting senescent cells in translational medicine
M Paez‐Ribes, E González‐Gualda… - EMBO molecular …, 2019 - embopress.org
Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …
The costs and benefits of senotherapeutics for human health
M Raffaele, M Vinciguerra - The Lancet Healthy Longevity, 2022 - thelancet.com
Cellular senescence is a major contributor to age-related diseases in humans; however, it
also has a beneficial role in physiological and pathological processes, including wound …
also has a beneficial role in physiological and pathological processes, including wound …
Strategies for targeting senescent cells in human disease
Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
Cellular senescence in age-related disorders
J Kaur, JN Farr - Translational Research, 2020 - Elsevier
Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …
Reducing senescent cell burden in aging and disease
Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …
characterized by irreversible growth arrest, apoptosis resistance, production of a …
Discovery, development, and future application of senolytics: theories and predictions
EO Wissler Gerdes, Y Zhu, T Tchkonia… - The FEBS …, 2020 - Wiley Online Library
Senescent cells accumulate with aging and at etiological sites of multiple diseases,
including those accounting for most morbidity, mortality, and health costs. Senescent cells …
including those accounting for most morbidity, mortality, and health costs. Senescent cells …
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
EOW Gerdes, Y Zhu, BM Weigand, U Tripathi… - International review of …, 2020 - Elsevier
Aging is the major predictor for developing multiple neurodegenerative diseases, including
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …
Targeting senescent cells for a healthier aging: challenges and opportunities
S Song, T Tchkonia, J Jiang, JL Kirkland… - Advanced …, 2020 - Wiley Online Library
Aging is a physiological decline in both structural homeostasis and functional integrity,
progressively affecting organismal health. A major hallmark of aging is the accumulation of …
progressively affecting organismal health. A major hallmark of aging is the accumulation of …
Cellular senescence: a translational perspective
JL Kirkland, T Tchkonia - EBioMedicine, 2017 - thelancet.com
Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …