Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of
life and increased health costs. To understand this disease, physicians have been studying …

There is a well-established historical observation that structural joint damage by plain X-ray
correlates poorly with symptomatic disease in osteoarthritis (OA). This is often attributed to …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

OA is a chronic arthritic disease characterized by pain, local tissue damage and attempts at
tissue repair. Historically, cartilage damage was believed to be the hallmark of OA. However …

Abstract Purpose of Review Osteoarthritis (OA) is the most common form of arthritis and a
major source of pain and disability worldwide. OA-associated pain is usually refractory to …

Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

Pain is a major clinical problem of osteoarthritis (OA). Recently, OA has been thought to be a
disease of the whole joint with both destruction of cartilage and inflammatory components …

Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

In this literature review, the mechanisms underlying pain associated with osteoarthritis (OA)
are discussed, along with evidence for the efficacy of medications thought to act centrally to …