Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive
skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy …

Background Denervation triggers numerous molecular responses in skeletal muscle,
including the activation of catabolic pathways and oxidative stress, leading to progressive …

Abstract Background Histone deacetylase 4 (HDAC4) has been proposed as a target for
Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction …

Skeletal muscle denervation causes muscle atrophy via complex molecular mechanisms
that are not well understood. To better understand these mechanisms, we investigated how …

Background Skeletal muscle atrophy is a common clinical manifestation of various
neurotrauma and neurological diseases. In addition to the treatment of primary …

Prolonged deficits in neural input activate pathological muscle remodeling, leading to
atrophy. In denervated muscle, activation of the atrophy program requires HDAC4, a potent …

Abstract Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that
mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles …

The absence of dystrophin in Duchenne muscular dystrophy disrupts the dystrophin-
associated glycoprotein complex resulting in skeletal muscle fiber fragility and atrophy …

HDACs are enzymes able to remodel the chromatin through histone deacetylation. The
hypothesis that alterations in chromatin remodeling participates in ALS progression comes …

HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to
denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially …