This unit describes the preparation of conjugates between nanometer‐scale gold particles
and synthetic oligonucleotides. Oligonucleotide‐functionalized gold nanoparticles are …

DNA functionalized gold-nanoparticles (Au-nps) have been broadly used as labeling
reagents in the development of molecular diagnostics as well as building blocks in …

Glutathione monolayer-protected gold clusters were reacted by place exchange with 19-or
20-residue thiolated oligonucleotides. The resulting DNA/nanoparticle conjugates could be …

We describe the synthesis of small (2-nm diameter) gold nanoparticles densely
functionalized with thiolated DNA (DNA-Au NPs) and a method to separate these particles …

Oligonucleotide− gold nanoparticle (OGN) conjugates are powerful tools for the detection of
target DNA sequences due to the unique properties conferred upon the oligonucleotide by …

In 1996, we reported a method for utilizing biomolecules, such as DNA, and their molecular
recognition properties to guide the assembly of nanoparticle building blocks modified with …

Fast modification of large gold nanoparticles with DNA is achieved by using DNA with a
polycationic tail. The conjugated DNA is available for specific hybridization, and therefore …

We have determined the minimum number of base pairings necessary to stabilize DNA− Au
NP aggregates as a function of salt concentration for particles between 15 and 150 nm in …

Highly-functionalized reagents can be produced from gold nanoparticles containing up to
seven different DNA oligonucleotide sequences (see picture). The individual oligomers are …

Functionalized gold nanoparticles have been covalently bound to internal, modified sites on
double-stranded DNA. Gold nanoparticles coated with mercaptosuccinic acid or thioctic acid …