In eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected
organelle responsible for the synthesis, folding, modification, and quality control of …

The endoplasmic reticulum (ER) is the site where proteins enter the secretory pathway.
Proteins are translocated into the ER lumen in an unfolded state and require protein …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

In all eukaryotic cells, the endoplasmic reticulum (ER) is an intracellular organelle where
folding and assembly occurs for proteins destined to the extracellular space, plasma …

The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER)
induces a coordinated adaptive program called the unfolded protein response (UPR). The …

The extensive membrane network of the endoplasmic reticulum (ER) is physically
juxtaposed to and functionally entwined with essentially all other cellular compartments …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

Proteins requiring post‐translational modifications such as N‐linked glycosylation are
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …

The endoplasmic reticulum (ER) is the principal cellular organelle in which correct folding
and maturation of transmembrane, secretory, and ER-resident proteins occur. Research …

The vast majority of proteins that a cell secretes or displays on its surface first enter the
endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled …