Acquisition and transfer of antibiotic resistance genes in association with conjugative plasmid or class 1 integrons of Acinetobacter baumannii

U Leungtongkam, R Thummeepak, K Tasanapak… - PLoS …, 2018 - journals.plos.org
Conjugation is a type of horizontal gene transfer (HGT) that serves as the primary
mechanism responsible for accelerating the spread of antibiotic resistance genes in Gram …

Interbacterial transfer of carbapenem resistance and large antibiotic resistance islands by natural transformation in pathogenic Acinetobacter

AS Godeux, E Svedholm, S Barreto, A Potron… - MBio, 2022 - Am Soc Microbiol
Acinetobacter baumannii infection poses a major health threat, with recurrent treatment
failure due to antibiotic resistance, notably to carbapenems. While genomic analyses of …

A large conjugative Acinetobacter baumannii plasmid carrying the sul2 sulphonamide and strAB streptomycin resistance genes

M Hamidian, SJ Ambrose, RM Hall - Plasmid, 2016 - Elsevier
Acinetobacter baumannii is an important nosocomial pathogen that often complicates
treatment because of its high level of resistance to antibiotics. Though plasmids can …

Characterization of class 1 integron resistance gene cassettes and the identification of a novel IS-like element in Acinetobacter baumannii

H Segal, R Thomas, BG Elisha - Plasmid, 2003 - Elsevier
Based on hybridization studies, 21/32 multi-resistant clinical isolates of Acinetobacter
baumannii contain class 1 integrons. Amplification products were obtained from 20 of the …

Treatment with Cefotaxime Affects Expression of Conjugation Associated Proteins and Conjugation Transfer Frequency of an IncI1 Plasmid in Escherichia coli

TSB Møller, G Liu, A Boysen, LE Thomsen… - Frontiers in …, 2017 - frontiersin.org
Horizontal gene transfer (HGT) is the major mechanism responsible for spread of antibiotic
resistance. Antibiotic treatment has been suggested to promote HGT, either by directly …

Insights on the Horizontal Gene Transfer of Carbapenemase Determinants in the Opportunistic Pathogen Acinetobacter baumannii

GJ Da Silva, S Domingues - Microorganisms, 2016 - mdpi.com
Horizontal gene transfer (HGT) is a driving force to the evolution of bacteria. The fast
emergence of antimicrobial resistance reflects the ability of genetic adaptation of pathogens …

Integron mobilization unit as a source of mobility of antibiotic resistance genes

L Poirel, A Carrër, JD Pitout… - Antimicrobial agents and …, 2009 - Am Soc Microbiol
Antibiotic resistance genes are spread mostly through plasmids, integrons (as a form of
gene cassettes), and transposons in gram-negative bacteria. We describe here a novel …

Spread of Carbapenem Resistance by Transposition and Conjugation Among Pseudomonas aeruginosa

A Van der Zee, WB Kraak, A Burggraaf… - Frontiers in …, 2018 - frontiersin.org
The emergence of carbapenem-resistant Pseudomonas aeruginosa represents a worldwide
problem. To understand the carbapenem-resistance mechanisms and their spreading …

[HTML][HTML] Horizontal gene transfer mediated bacterial antibiotic resistance

D Sun, K Jeannot, Y Xiao, CW Knapp - Frontiers in microbiology, 2019 - frontiersin.org
Bacterial antibiotic resistance, especially multidrug resistance (MDR), has become a global
challenge, threatening human and animal health, food, and environment safety. The number …

[HTML][HTML] Antibiotic-induced, increased conjugative transfer is common to diverse naturally occurring ESBL plasmids in Escherichia coli

G Liu, K Bogaj, V Bortolaia, JE Olsen… - Frontiers in …, 2019 - frontiersin.org
Previously, we showed that cefotaxime (CTX) exposure increases conjugative transfer of a
bla CTX–M–1 encoding IncI1 plasmid (IncI1/pST49/CTX-M-1) in Escherichia coli in a SOS …