Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts

C Zhang, XY Wang, P Zhang, TC He, JH Han… - Cell death & …, 2022 - nature.com
Tumor metastasis is a hallmark of cancer. The communication between cancer-derived
exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche …

Investigation of the roles of exosomes in colorectal cancer liver metastasis

X Wang, X Ding, L Nan, Y Wang… - Oncology …, 2015 - spandidos-publications.com
The leading cause of death among cancer patients is tumor metastasis. Tumor-derived
exosomes are emerging as mediators of metastasis. In the present study, we demonstrated …

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

M He, H Qin, TCW Poon, SC Sze, X Ding… - …, 2015 - academic.oup.com
Exosomes are increasingly recognized as important mediators of cell–cell communication in
cancer progression through the horizontal transfer of RNAs and proteins to neighboring or …

Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3

H Sun, C Wang, B Hu, X Gao, T Zou, Q Luo… - Signal transduction and …, 2021 - nature.com
Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how
these cancer cells interact with each other is still largely unknown. Exosomes released by …

Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis

M Li, Y Lu, Y Xu, J Wang, C Zhang, Y Du, L Wang, L Li… - Gene, 2018 - Elsevier
Exosomes have been demonstrated as an important factor to influence cancer invasion and
metastasis. Previous studies have shown that CXC chemokine recepter-4 (CXCR4) and …

Hepatocellular carcinoma-derived exosomes in organotropic metastasis, recurrence and early diagnosis application

Y Ge, W Mu, Q Ba, J Li, Y Jiang, Q Xia, H Wang - Cancer Letters, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, despite
improvements in the clinical trial and diagnosis, HCC still remains high mortality due to the …

Exosomes derived from HCC cells with different invasion characteristics mediated EMT through TGF-β/Smad signaling pathway

Z Qu, J Feng, H Pan, Y Jiang, Y Duan… - OncoTargets and …, 2019 - Taylor & Francis
Background Exosomes are nano-sized biological vesicles released by many kinds of cells,
which play an important role in tumor metastasis through transporting cytokines, RNAs and …

[HTML][HTML] Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation

Z Yu, S Zhao, L Ren, L Wang, Z Chen, RM Hoffman… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Exosomes play important roles in cell-cell communication, and are likely mediators of the
metastatic cascade in cancer. This study examined the role of exosomes in pancreatic …

Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer

Q Fu, Q Zhang, Y Lou, J Yang, G Nie, Q Chen, Y Chen… - Oncogene, 2018 - nature.com
Hepatocellular carcinoma (HCC) is a fatal disease and patients with HCC frequently die
from metastasis. The mechanisms of HCC metastasis are not completely understood. In the …

Hypoxia‐inducible exosomes facilitate liver‐tropic premetastatic niche in colorectal cancer

H Sun, Q Meng, C Shi, H Yang, X Li, S Wu… - …, 2021 - Wiley Online Library
Background and Aims Liver metastasis is a frequent occurrence in patients with colorectal
cancer (CRC), with 15%‐25% of CRC patients having liver metastases at the time of initial …