Faced with the reality of our current methods of drug discovery and toxicity assessment of all
chemicals is less than perfect, the Report,''Toxicity Testing in the 21 st Century: A Vision and …

Given the reality of the inadequacies of current concepts of the mechanisms of chemical
toxicities, of the various assays to predict toxicities from current molecular, biochemical, in …

Environmental pollution is a global problem; the lack of comprehensive toxicological
assessments may lead to increased health risks. To fully understand the health effects of …

The field of environmental toxicology has been challenged in the last few decades by the
exponential discovery of novel persistent pollutants and the relative lack of knowledge of …

Abstract The National Research Council's (NRC) toxicity testing vision lays out a bold future
for our field. It depends heavily on computational algorithms based on the latest knowledge …

Chemicals are known to be associated with birth defects, cancer, cardiovascular diseases,
immunological, reproductive, and neurological disorders. In response to recent reviews of …

This “Commentary” has examined the use of human stem cells for detection of toxicities of
physical, chemical, and biological toxins/toxicants in response to the challenge posed by the …

The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …

The development of stem cell biology has revolutionized regenerative medicine and its
clinical applications. Another aspect through which stem cells would benefit human health is …

Human stem cells and their derivatives could provide virtually unlimited sources of tissue for
a wide range of toxicity models that could complement conventional animal models with …