Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents

S Minabe, C Deura, K Ikegami, T Goto, M Sanbo… - …, 2015 - academic.oup.com
Ependymocytes are one of the energy-sensing cells that regulate animal reproduction
through their responsiveness to changes in extracellular glucose levels and the expression …

Role of AMPK in mammals reproduction: Specific controls and whole-body energy sensing

TMD Nguyen - Comptes Rendus Biologies, 2019 - Elsevier
AMP-activated protein kinase (AMPK) is a key enzyme involved in linking the energy
sensing to metabolic pathways. As such, it plays a central role at the whole-body level to …

Roles of AMP-activated protein kinase (AMPK) in mammalian reproduction

W Yang, L Wang, F Wang, S Yuan - Frontiers in Cell and …, 2020 - frontiersin.org
Reproduction is an energy demanding function and only take place in case of sufficient
available energy status in mammals. Metabolic diseases such as anorexia nervosa are …

AMPK: a master energy regulator for gonadal function

MJ Bertoldo, M Faure, J Dupont… - Frontiers in neuroscience, 2015 - frontiersin.org
From C. elegans to mammals (including humans), nutrition and energy metabolism
significantly influence reproduction. At the cellular level, some detectors of energy status …

AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction

D Franssen, A Barroso, F Ruiz-Pino, MJ Vázquez… - Metabolism, 2021 - Elsevier
Background Reproduction is tightly coupled to body energy and metabolic status. GnRH
neurons, master elements and final output pathway for the brain control of reproduction …

Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality

MJ Bertoldo, E Guibert, M Faure, F Guillou… - Molecular and Cellular …, 2016 - Elsevier
The AMP-activated protein kinase (AMPK) is an important regulator of cellular energy
homeostasis which plays a role in fertility. Complete disruption of the AMPK catalytic subunit …

Inactivation of AMPKα1 induces asthenozoospermia and alters spermatozoa morphology

P Tartarin, E Guibert, A Touré, C Ouiste… - …, 2012 - academic.oup.com
AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, is
present in metabolic tissues (muscle and liver) and has been identified as a modulator of the …

[HTML][HTML] 5'-AMP-Activated protein kinase regulates goat sperm functions via energy metabolism in vitro

Z Zhu, R Li, G Ma, W Bai, X Fan, Y Lv, J Luo… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: ATP is essential for mammalian sperm to survive and maintain fertilizing
capacity. AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. The …

The effect of AMP‐activated kinase activation on gonadotrophin‐releasing hormone secretion in GT1‐7 cells and its potential role in hypothalamic regulation of the …

S Coyral‐Castel, L Tosca, G Ferreira… - Journal of …, 2008 - Wiley Online Library
Hypothalamic AMP‐activated kinase (AMPK) is a key regulator of food intake in mammals.
Its role in reproduction at the central level and, more precisely, in gonadotrophin‐releasing …

AMPK function in mammalian spermatozoa

D Martin-Hidalgo, A Hurtado de Llera… - International journal of …, 2018 - mdpi.com
AMP-activated protein kinase AMPK regulates cellular energy by controlling metabolism
through the inhibition of anabolic pathways and the simultaneous stimulation of catabolic …