The matrix of the lung parenchyma is composed predominantly of collagen, elastin,
glycosaminoglycans, and fibronectin. This presentation focuses on the newer insights into …

In addition to providing structural support and defining tissue compartments, the lung's
extracellular matrix plays an important role in regulating cell behavior. Normal and …

S. Endlcott, MD; ond S. Sla4piro, MD Elastin injury and subsequent imperfect repair are held
to be pivotal events in the pathogenesis of pulmonary emphysema. However, little is known …

Elastin is expressed in most tissues that require elastic recoil. The protein first appeared
coincident with the closed circulatory system, and was critical for the evolutionary success of …

Connective tissue forms the bulk of the extracellular components of the lung and plays a
critical role in de8ning lung function in health and disease. One group of pulmonary …

During lung development the extracellular matrix regulates cellular growth, migration, and
differentiation. Pulmonary cells reciprocate and regulate extracellular matrix formation by …

This study was undertaken to test whether there is structural remodeling of lung parenchyma
that could lead to tissue mechanical changes at an early phase of varying degrees of acute …

Degradation and restructuring of the elastin fiber network of the lung is a pivotal process in
the pathogenesis of emphysema. Alveolar macrophages and neutrophils are probably …

Elastin is a chief component of lung interstitium, and it is central to lung morphology and
function. Efforts to understand the pathogenesis of pulmonary fibrosis have focused primarily …

Elastic fibers are ubiquitous in the lung. They are found throughout the pulmonary
interstitium, within the walls of blood vessels, and in the pleura (Figure 1). The functional …