Collagen and elastin are thought to dominate the elasticity of the connective tissue including
lung parenchyma. The glycosaminoglycans on the proteoglycans may also play a role …

Lung injury and matrix destruction result in the release into the circulation of desmosine, a
product of elastin catabolism. To determine whether measurements of desmosine …

Male LAF/1 mice were locally irradiated at doses of 5, 9, and 13 Gy and compared with
untreated and sham-irradiated animals. Lungs were subsequently examined at times of 1, 4 …

The lungs of male mice were locally irradiated with graded doses of radiation ranging from 5
to 13 Gy. The animals were sacrificed at 1 hr, 1 day, 1 week, 4 weeks, and 12 weeks …

Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide and is
now the third leading cause of death in the United States. There is a lack of therapies that …

Macrophage and neutrophil proteinases damage lung elastin, disrupting alveolar epithelium
and filling alveoli with inflammatory exudate. Alveolar collapse and regional hypoxia occur …

It has been postulated that elastolytic breakdown of pulmonary connective tissue is the
primary insult leading to emphysematous lesions in patients and experimental animals. In …

Previously we have shown that treatment of confluent, pulmonary fibroblast cultures with
elastase results in upregulation of elastin mRNA and protein levels. In the present study we …

Cigarette smoking is the strongest risk factor for emphysema. However, sensitivity to
cigarette smoke-induced emphysema is highly variable, and numerous genetic and …

It is essential that the framework of all multicellular organisms should include some materials
with high tensile strength and rigidity, such as bone and collagen, to maintain shape and …