Eight series of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …

Six series of quinazoline derivatives bearing oxazole or imidazole (8a–f, 9a–f, 10a–d, 11a–f,
12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against …

Two series of quinazoline derivatives bearing aryl semicarbazone scaffolds (9a–o and 10a–
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …

Aimed at discovering effective EGFR inhibitors, six series of quinazoline derivatives bearing
a semicarbazone moiety were designed, synthesized and evaluated in different cancer cell …

EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …

The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …

Epidermal growth factor receptor (EGFR) is the most attractive target for drug research in
non-small cell lung cancer (NSCLC). The first-generation EGFR tyrosine kinase inhibitors …

Abstract A series of novel 6, 7-dimorpholinoalkoxy quinazoline derivatives was designed,
synthesized and evaluated as potent EGFR inhibitors. Most of synthesized derivatives …

Abstract A class of 2-aryl-4-aminoquinazoline derivatives (7a-7j, 8a-8h, 9a-9h and 10a-10k)
were designed, synthesized and evaluated as EGFR inhibitors. The anti-proliferative activity …

The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …