Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation
K Seggerson, L Tang, EG Moss - Developmental biology, 2002 - Elsevier
The heterochronic gene lin-28 of the nematode Caenorhabditis elegans controls the relative
timing of diverse developmental events during the animal's larval stages. lin-28 is stage …
timing of diverse developmental events during the animal's larval stages. lin-28 is stage …
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
Heterochronic genes form a regulatory pathway that controls the temporal sequence of the
Caenorhabditis elegans postembryonic cell lineage. One of these genes, lin-14, encodes a …
Caenorhabditis elegans postembryonic cell lineage. One of these genes, lin-14, encodes a …
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
PH Olsen, V Ambros - Developmental biology, 1999 - Elsevier
lin-4 encodes a small RNA that is complementary to sequences in the 3′ untranslated
region (UTR) of lin-14 mRNA and that acts to developmentally repress the accumulation of …
region (UTR) of lin-14 mRNA and that acts to developmentally repress the accumulation of …
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
B Wightman, I Ha, G Ruvkun - Cell, 1993 - Elsevier
During C. elegans development, the temporal pattern of many cell lineages is specified by
graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal …
graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal …
The Timing oflin-4RNA Accumulation Controls the Timing of Postembryonic Developmental Events inCaenorhabditis elegans
R Feinbaum, V Ambros - Developmental biology, 1999 - Elsevier
Thelin-4gene encodes a small RNA that is required to translationally represslin-14toward
the end of the first larval stage ofCaenorhabditis elegansdevelopment. To determine if the …
the end of the first larval stage ofCaenorhabditis elegansdevelopment. To determine if the …
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
RC Lee, RL Feinbaum, V Ambros - cell, 1993 - cell.com
Summary h-4 is essential for the normal temporal control of diverse postembryonic
developmental events in C. elegans./in-4 acts by negatively regulating the level of LIN-14 …
developmental events in C. elegans./in-4 acts by negatively regulating the level of LIN-14 …
[HTML][HTML] Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites
EG Moss, L Tang - Developmental biology, 2003 - Elsevier
The heterochronic gene lin-28 is a regulator of developmental timing in the nematode
Caenorhabditis elegans. It must be expressed in the first larval stage and downregulated by …
Caenorhabditis elegans. It must be expressed in the first larval stage and downregulated by …
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
B Wightman, TR Bürglin, J Gatto, P Arasu… - Genes & …, 1991 - genesdev.cshlp.org
The heterchronic gene lin-14 controls the temporal sequence of developmental events in the
Caenorhabditis elegans postembryonic cell lineage. It encodes a nuclear protein that …
Caenorhabditis elegans postembryonic cell lineage. It encodes a nuclear protein that …
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
Null mutations in the C. elegans heterochronic gene lin-41 cause precocious expression of
adult fates at larval stages. Increased lin-41 activity causes the opposite phenotype …
adult fates at larval stages. Increased lin-41 activity causes the opposite phenotype …
Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.
G Ruvkun, V Ambros, A Coulson, R Waterston… - Genetics, 1989 - academic.oup.com
We describe a general strategy for the genetic mapping in parallel of multiple restriction
fragment length polymorphism (RFLP) loci. This approach allows the systematic …
fragment length polymorphism (RFLP) loci. This approach allows the systematic …
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