Objectives Apoptosis is defined as programmed cell death, which regulates cellular
functions and various physiological responses. Several studies reported that Caspase …

Abstract Purpose Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in
regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was …

Objective Caspase-8 (CASP8) plays a central role in the apoptotic pathway and aberrant
regulation of this pathway may cause cancers. Previous studies investigating the association …

Purpose Caspase 8 (CASP8) plays a critical role in the apoptotic pathway and aberrant
regulation of this pathway causes many diseases including cancers. Genetic variants …

Abstract Caspase-8 (CASP8), member of the caspase cysteine protease family, plays an
important role in cancer development. CASP8 D302H (rs1045485)(D, Aspartate; H …

Abstract Caspase-8 (CASP8) is one key regulator of apoptosis of T lymphocytes and is
encoded by the CASP8 gene. It has been reported that the six-nucleotide deletion …

Abstract Background Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in
regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was …

Abstract The initiators caspase-9 (CASP9) and caspase-10 (CASP10) are two key
controllers of apoptosis and play important roles in carcinogenesis. This study aims to …

Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in
apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 …

The common− 652 6N del variant in the CASP8 promoter (rs3834129) has been described
as a putative low-penetrance risk factor for different cancer types. In particular, some studies …