Context People experiencing possible prodromal symptoms of psychosis have a very high
risk of developing the disorder, but it is not possible to predict, on the basis of their …

It remains unclear whether brain structural abnormalities observed before the onset of
psychosis are specific to schizophrenia or are common to all psychotic disorders. This study …

Individuals at ultra-high-risk (UHR) for psychosis have become a major focus for research
designed to explore markers for early detection of and clinical intervention in schizophrenia …

Context Magnetic resonance imaging studies have identified hippocampal volume
reductions in schizophrenia and amygdala volume enlargements in bipolar disorder …

Background: Ultra-high risk (UHR) for psychosis has been associated with widespread
structural brain changes in young adults. The onset of these changes and their subsequent …

BackgroundNeuroanatomical abnormalities are a well-established feature of schizophrenia.
However, the timing of their emergence and the extent to which they are related to …

BACKGROUND: While structural brain imaging abnormalities have been identified in
schizophrenia and related disorders, it is unclear when they arise. Some appear to predate …

BACKGROUND: Individual structural imaging studies in the pre-psychotic phases deliver
contrasting findings and are unable to definitively characterize the neuroanatomical …

Background: Accumulating evidence from postmortem and magnetic resonance imaging
(MRI) studies suggests that abnormalities of medial temporal lobe structures are critically …

BACKGROUND: Schizophrenia and related psychoses are associated with brain structural
abnormalities. Recent findings in 'at risk'populations have identified progressive changes in …