The prevalence of cerebral palsy (CP) shows little temporal or geographic variation and is
associated with preterm birth, maternal/fetal infection/inflammation, and fetal growth …

Brain injury around birth is associated with nearly half of all cases of cerebral palsy.
Although brain injury is multifactorial, particularly after preterm birth, acute hypoxia …

Background Fetal hypoxia causes vital, systemic, developmental malformations in the fetus,
particularly in the brain, and increases the risk of diseases in later life. We previously …

The main cause of hypoxic/ischemic brain damage in term human neonates is intrauterine
asphyxia, in which the whole body is subjected to hypoxia. Inflammatory cytokines are …

Gestational hypoxia is a common stress to the fetal development and increases the risk of
neonatal morbidity. The present study tested the hypothesis that fetal hypoxia results in …

The fetal origins of adult disease (FOAD) hypothesis, which was proposed by David Barker
in the United Kingdom in the late 1980s, posited that adult chronic diseases originated from …

Background Infants born preterm commonly suffer from a combination of hypoxia-ischemia
(HI) and infectious perinatal inflammatory insults that lead to cerebral palsy, cognitive delay …

Disruption to the maternal environment during pregnancy from events such as hypoxia,
stress, toxins, inflammation, and reduced placental blood flow can affect fetal development …

The impact of transient ischemic-hypoxemic insults on the developing fetal brain is poorly
understood despite evidence suggesting an association with neurodevelopmental disorders …

Late-gestational intrauterine hypoxia represents a well-known risk factor of acquired
perinatal brain injury. Cell type and age-specific sensitivity of hypoxia-responsive genes to …