While the technique of homologous recombination, or gene targeting, has led to the
generation of transgenic mice of great value to biomedical research, similar approaches are …

In contrast to the highly developed genetic modification systems available for manipulating
the mouse genome, at this time only simple gain of function modifications can be undertaken …

The notion of directly introducing new genes or otherwise directly manipulating the genotype
of an animal is conceptually straightforward and appealing because of the speed and …

Since the initial demonstration in 1982 of profound phenotypic effects stemming from the
expression of a single transgene, genetic engineering has revolutionized fundamental …

Transgenic livestock came into existence in 1985 with the production of the first transgenic
pigs and sheep (Hammer et al., 1985). Since then, various technologies have been …

The notion of directly introducing new genes or otherwise manipulating the genotype of an
animal is conceptually straightforward and appealing from the standpoints of both speed …

The field of xenotransplantation is benefiting greatly from recent advances in genetic
engineering. The efficiency and pace with which new model animals are being created has …

One of the most powerful strategies to investigate biology we have as scientists, is the ability
to transfer genetic material in a controlled and deliberate manner between organisms. When …

Domestic animals can be cloned using techniques such as embryo splitting and nuclear
transfer to produce genetically identical individuals. Although embryo splitting is limited to …

Genome editing tools enable efficient and accurate genome manipulation. An enhanced
ability to modify the genomes of livestock species could be utilized to improve disease …