[HTML][HTML] Increased expression of Six1 correlates with progression and prognosis of prostate cancer

J Zeng, R Shi, C Cai, X Liu, Y Song, M Wei… - Cancer cell international, 2015 - Springer
Abstract Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted
transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences …

[HTML][HTML] Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma

L Chao, J Liu, D Zhao - Oncology letters, 2017 - spandidos-publications.com
Sine oculis homeobox homolog 1 (Six1) is an evolutionarily conserved transcription factor
that acts as master regulator of development and is frequently dysregulated in various types …

Sineoculis homeobox homolog 1 protein overexpression as an independent biomarker for pancreatic ductal adenocarcinoma

A Jin, Y Xu, S Liu, T Jin, Z Li, H Jin, L Lin… - … and Molecular Pathology, 2014 - Elsevier
Abstract Sineoculis homeobox homolog 1 (SIX1) is a member of the SIX gene family. It is
highly expressed in cancers derived from tissues that play a fundamental role during …

[HTML][HTML] SIX1 is overexpressed in endometrial carcinoma and promotes the malignant behavior of cancer cells through ERK and AKT signaling

X Xin, Y Li, X Yang - Oncology letters, 2016 - spandidos-publications.com
The sineoculis homeobox homolog 1 (SIX1) protein has been found to be important for
cancer progression. However, its biological role in human endometrial carcinomas remains …

Inhibition of Six1 promotes apoptosis, suppresses proliferation, and migration of osteosarcoma cells

L Hua, L Fan, W Aichun, Z Yongjin, C Qingqing… - Tumor Biology, 2014 - Springer
Abstract Sineoculis homeobox homolog 1 (Six1) is one of the transcription factors that act as
master regulators of development and is frequently dysregulated in cancers. However, the …

Six1: a critical transcription factor in tumorigenesis

W Wu, Z Ren, P Li, D Yu, J Chen… - … journal of cancer, 2015 - Wiley Online Library
In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a
powerful regulator of organogenesis and disease, with important roles in tumorigenesis; …

[HTML][HTML] The significance of SIX1 as a prognostic biomarker for survival outcome in various cancer patients: a systematic review and meta-analysis

G Zhu, Y Liu, L Zhao, Z Lin, Y Piao - Frontiers in Oncology, 2021 - frontiersin.org
Sine Oculis Homeobox Homolog 1 (SIX1) is reported to promote cancer initiation and
progression in many preclinical models and is demonstrated in human cancer tissues …

[HTML][HTML] Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma

ML Mo, J Okamoto, Z Chen, T Hirata, I Mikami… - PloS one, 2013 - journals.plos.org
Background Lung cancer is a common cancer and the leading cause of cancer-related
death worldwide. SIX3 is a human homologue of the highly conserved sine oculis gene …

Overexpression of SIX1 is an independent prognostic marker in stage I–III colorectal cancer

C Kahlert, T Lerbs, M Pecqueux… - … journal of cancer, 2015 - Wiley Online Library
Epithelial‐to‐mesenchymal transition (EMT) contributes significantly to tumor progression
and metastasis. The assessment of EMT‐associated transcription factors could be a …

[HTML][HTML] Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression

Z Li, T Tian, F Lv, Y Chang, X Wang, L Zhang, X Li, L Li… - PloS one, 2013 - journals.plos.org
Six1 is one of the transcription factors that act as master regulators of development and are
frequently dysregulated in cancers. However, the role of Six1 in pancreatic cancer is not …