It was found recently that iron overload can cause osteoporosis in rats. Through in vitro and
in vivo experimentations, the purpose of the present study was to validate and confirm the …

Background The protective effect of melatonin against bone metabolism imbalance in
osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this …

Oxidative stress is an important contributor to the development of osteoporosis. Melatonin,
an indoleamine secreted by the pineal gland, has antioxidant properties. This study aims to …

Osteoblastic differentiation and bone‐forming capacity are known to be suppressed under
hypoxic conditions. Melatonin has been shown to influence cell differentiation. A number of …

It has been shown that melatonin may affect bone metabolism. However, it is controversial
whether melatonin could promote osteoblast proliferation, and the precise molecular …

Previous studies have revealed that melatonin could play a role in anti-osteoporosis and
promoting osteogenesis. However, the effects of melatonin treatment on osteoporotic bone …

Background: Previous studies reported that melatonin exerts its effect on mesenchymal stem
cell (MSC) survival and differentiation into osteogenic and adipogenic lineage. In the current …

Background Osteoporosis is a disease threatening the health of millions of individuals.
Melatonin is found to be a potential anti-osteoporosis drug. However, whether melatonin …

Although melatonin has a variety of biological actions such as antitumor, antiangiogenic,
and antioxidant activities, the osteogenic mechanism of melatonin still remains unclear …

Ferroptosis is recently identified, an iron‐and reactive oxygen species‐(ROS‐) dependent
form of regulated cell death. This study was designed to determine the existence of …