Adenosine deaminases acting on RNA (ADARs) convert adenosines to inosines in double-
stranded RNA (dsRNA) in animals. Despite their importance, ADAR RNA substrates have …

The Zα domains represent a growing subfamily of the winged helix-turn-helix (HTH) domain
family whose members share a remarkable ability to bind specifically to Z-DNA and/or Z …

Adenosine deaminases acting on RNA (ADARs) are editing enzymes that convert
adenosine to inosine in duplex RNA, a modification reaction with wide-ranging …

Eukaryotic cells use multiple, highly conserved mechanisms to contend with ultraviolet-light-
induced DNA damage. One important response mechanism is transcription-coupled repair …

Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded
RNA (dsRNA). ADAR1p150 suppresses the dsRNA-sensing mechanism that activates …

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …

Double-stranded RNA (dsRNA) plays a centrally important role in antiviral innate immunity,
both for the production of interferon (IFN) and also in the actions of IFN. Among the IFN …

Drosophila melanogaster and Caenorhabditis elegans strains lacking all ADAR activity are
viable but exhibit behavioral defects (2, 3), whereas mice lacking ADARs die embryonically …

Abstract Left-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain protein
family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral …

Transposable elements are viewed as 'selfish genetic elements', yet they contribute to gene
regulation and genome evolution in diverse ways. More than half of the human genome …