Background and purpose Xanthine oxidoreductase (XOR), which catalyzes purine
catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase …

The free radical-generating enzyme xanthine oxidase has been hypothesized to be a central
mechanism of the injury which occurs in postischemic tissues; however, its importance …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Emerging evidence supports the importance of nitroso-redox balance in the cardiovascular
system. Xanthine oxidoreductase (XOR) is a major oxidative enzyme and increased XOR …

In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been
implicated in the development of tissue oxidative damage in a wide variety of respiratory and …

Objective: Cardiac injury, related to ischaemia and reperfusion, may be caused by the action
of oxygen free radicals. Xanthine oxidoreductase activity may be an important free radical …

Aims Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal
muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial …

Xanthine oxidoreductase is an important cytoplasmic source of reactive oxygen species, and
has been implicated in the pathogenesis of ischemia-reperfusion damage. Because the …

After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …

While the free radical-generating enzyme xanthine oxidase is a central mechanism of injury
in postischemic tissues, questions remain regarding how xanthine oxidase-mediated radical …