Previous studies have suggested that the two subunits of phosphatidylinositol (PI) 3-kinase,
p85 and p110, function as localizing and catalytic subunits, respectively. Using recombinant …

Abstract Phosphatidylinositol (PI) 3-kinase is a heterodimer consisting of an 85-kDa subunit
(p85) and 110-kDa subunit (p110). The 85-kDa noncatalytic subunit, which contains two Src …

Abstract Phosphatidylinositol 3-kinase (PI 3-kinase) has been implicated as a participant in
signaling pathways regulating cell growth by virtue of its activation in response to various …

Phosphatidylinositol (PI) 3‐kinase has an 85 kDa subunit (p85 alpha) which mediates its
association with activated protein tyrosine kinase receptors through SH2 domains, and an …

The regulatory (p85 alpha) and catalytic (p110 alpha) subunits of the mammalian
phosphatidylinositol 3-kinase have been expressed in insect cells using the baculovirus …

Phosphatidylinositol (PI) 3-kinase is a heterodimeric enzyme of 85-kDa (p85) and 110-kDa
(p110) subunits implicated in mitogenic signal transduction by virtue of its activation in cells …

Phosphatidylinositol 3-kinase, which is composed of a 110-kDa catalytic subunit and a
regulatory subunit, plays important roles in various cellular signaling mechanisms. We …

Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by association with a variety of
tyrosine kinase receptors and intracellular tyrosine-phosphorylated substrates. We isolated …

Domains of interaction between the p85 and p110 subunits of phosphatidylinositol 3-kinase
(PI 3-kinase) were studied with the yeast two-hybrid expression system. A gene fusion …

Purified bovine brain phosphatidylinositol 3-kinase (PI3-kinase) is composed of 85 kd and
110 kd subunits. The 85 kd subunit (p85α) lacks PI3-kinase activity and acts as an adaptor …