Intravenous artesunate for the treatment of severe malaria

KM Hess, JA Goad, PM Arguin - Annals of Pharmacotherapy, 2010 - journals.sagepub.com
Objective: To review the pharmacodynamics and pharmacotherapeutic use of intravenous
artesunate for the treatment of severe malaria. Data Sources: Literature was retrieved …

Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium

AR Kreeftmeijer-Vegter, PJ van Genderen, LG Visser… - Malaria journal, 2012 - Springer
Background Intravenous (IV) artesunate is the treatment of choice for severe malaria. In
Europe, however, no GMP-manufactured product is available and treatment data in …

Artesunate: the best drug in the treatment of severe and complicated malaria

Q Li, P Weina - Pharmaceuticals, 2010 - mdpi.com
This review summarizes progress in treating severe and complicated malaria, which are
global problems, claiming at least one million lives annually, and have been accompanied …

Systematic review of artesunate pharmacokinetics: Implication for treatment of resistant malaria

YI Kouakou, M Tod, G Leboucher, A Lavoignat… - International Journal of …, 2019 - Elsevier
Background Artesunate (ART) is an artemisinin derivative used as monotherapy for the
treatment of severe malaria and in combination with a partner drug for non-severe malaria …

Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: phase 1b study

RS Miller, Q Li, LR Cantilena, KJ Leary, GA Saviolakis… - Malaria journal, 2012 - Springer
Background Severe malaria results in over a million deaths every year, most of them in
children aged less than five years and living in sub-Saharan Africa. Injectable artesunate …

Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults

P Byakika-Kibwika, M Lamorde, J Mayito, L Nabukeera… - Malaria journal, 2012 - Springer
Background Severe malaria is a medical emergency with high mortality. Prompt
achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the …

The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria

PN Newton, KI Barnes, PJ Smith, AC Evans… - European journal of …, 2006 - Springer
Objective Intravenous artesunate is commonly used in the emergency treatment of patients
with severe falciparum malaria in Asia. The choice of doses used has been empirical. To …

[HTML][HTML] Expanded availability of intravenous artesunate for the treatment of severe malaria in the United States

PJ Rosenthal, KR Tan - The American Journal of Tropical Medicine …, 2019 - ncbi.nlm.nih.gov
Malaria remains one of the most important infectious diseases in the world. The WHO
estimated 435,000 deaths from malaria in 2017, the large majority due to Plasmodium …

Intravenous artesunate recommended for patients with severe malaria: position statement from TropNetEurop

T Jelinek - Weekly releases (1997–2007), 2005 - eurosurveillance.org
Eurosurveillance | Intravenous artesunate recommended for patients with severe malaria:
position statement from TropNetEurop 1887 Other sites: ECDC European Antibiotic …

Artesunate: a review of its pharmacology and therapeutic efficacy in the treatment of malaria

LB Barradell, A Fitton - Drugs, 1995 - Springer
Synopsis Artesunate is an antimalarial agent, available in oral, rectal and parenteral
formulations, that provides a rapid clinical effect in patients with Plasmodium falciparum …