Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following
biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that …

Retinoblastoma is a retinal cancer that is initiated in response to biallelic loss of RB1 in
almost all cases, together with other genetic/epigenetic changes culminating in the …

Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular
tumor worldwide. Despite tremendous breakthroughs in our understanding of the …

Background Retinoblastoma is a pediatric eye cancer associated with RB1 loss or MYCN
amplification (RB1+/+ MYCN A). There are controversies concerning the existence of …

Retinoblastoma is a rare childhood cancer initiated by RB1 mutation or MYCN amplification,
while additional alterations may be required for tumor development. However, the view on …

Retinoblastoma is a rare childhood cancer of the developing retina, and studies on this
orphan disease have led to fundamental discoveries in cancer biology. Retinoblastoma has …

Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the
retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has …

Retinoblastoma has contributed much to the understanding of cancer. It provided the classic
'two-hit model'for oncogenesis and helped to identify the first tumor suppressor gene RB1 …

Retinoblastoma is the most common malignant ocular tumor in children. Although RB1
alterations are most frequently involved in the etiology of retinoblastoma, candidate driver …

Retinoblastoma is the most frequent intraocular malignancy in children. Little is known on
the molecular basis underlying the biological and clinical behavior of this cancer. Here …