Single-dose, open-label study of the differences in pharmacokinetics of colchicine in subjects with renal impairment, including end-stage renal disease
S Wason, D Mount, R Faulkner - Clinical drug investigation, 2014 - Springer
Abstract Background and Objective The effect of renal impairment on colchicine
pharmacokinetics in patients with chronic kidney disease (CKD) has not been studied …
pharmacokinetics in patients with chronic kidney disease (CKD) has not been studied …
Adverse events of colchicine for cardiovascular diseases: a comprehensive meta-analysis of 14 188 patients from 21 randomized controlled trials
A Andreis, M Imazio, S Avondo, M Casula… - Journal of …, 2021 - journals.lww.com
Aims Colchicine has an emerging role in the cardiovascular field, although, concerns for
side effects, especially gastrointestinal, limit its prescription. We aimed at evaluating …
side effects, especially gastrointestinal, limit its prescription. We aimed at evaluating …
Colchicine
SL Wallace - Seminars in arthritis and rheumatism, 1974 - Elsevier
The clinical pharmacology of colchicine has been reviewed and its therapeutic use
described. There is still some disagreement about its diagnostic utility; it is clearly most …
described. There is still some disagreement about its diagnostic utility; it is clearly most …
Colchicine pharmacokinetics and mechanism of action
C Angelidis, Z Kotsialou, C Kossyvakis… - Current …, 2018 - ingentaconnect.com
Colchicine is a tricyclic, lipid-soluble alkaloid derived from the plant of the Lily family
Colchicum autumnale, sometimes called the “autumn crocus”. It is predominantly …
Colchicum autumnale, sometimes called the “autumn crocus”. It is predominantly …
Colchicine revisited
A Bhat, SM Naguwa, GS Cheema… - Annals of the New …, 2009 - Wiley Online Library
Purified from a Mediterranean plant nearly two centuries ago, colchicine has been
discovered to inhibit many steps in the inflammatory process. The drug has good oral …
discovered to inhibit many steps in the inflammatory process. The drug has good oral …
Cardiovascular effects and safety of long-term colchicine treatment: Cochrane review and meta-analysis
LG Hemkens, H Ewald, VL Gloy, A Arpagaus, KK Olu… - Heart, 2016 - heart.bmj.com
Colchicine is an old anti-inflammatory drug that has shown substantial cardiovascular
benefits in recent trials. We systematically reviewed cardiovascular benefits and harms of …
benefits in recent trials. We systematically reviewed cardiovascular benefits and harms of …
Colchicine: a review on chemical structure and clinical usage
For many years, colchicine has been used for therapeutic purposes and has been given
considerable attention because of its association with tubulin and inhibition of small tubular …
considerable attention because of its association with tubulin and inhibition of small tubular …
Colchicine in cardiovascular disease: in-depth review
SG Deftereos, FJ Beerkens, B Shah, G Giannopoulos… - Circulation, 2022 - Am Heart Assoc
Inflammation plays a prominent role in the development of atherosclerosis and other
cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular …
cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular …
Colchicine poisoning: the dark side of an ancient drug
Y Finkelstein, SE Aks, JR Hutson, DN Juurlink… - Clinical …, 2010 - Taylor & Francis
Introduction. Colchicine is used mainly for the treatment and prevention of gout and for
familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut …
familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut …
Adverse events during oral colchicine use: a systematic review and meta-analysis of randomised controlled trials
S Stewart, KCK Yang, K Atkins, N Dalbeth… - Arthritis research & …, 2020 - Springer
Background Colchicine is a widely used drug to treat inflammatory diseases. Due to its long
historical use in medicine, controlled clinical trials have been small and there remains some …
historical use in medicine, controlled clinical trials have been small and there remains some …