Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements
CYA Chen, AB Shyu - Molecular and cellular biology, 1994 - Taylor & Francis
The metabolic lifetime of mRNA can be specified by specific cis-acting elements within
mRNA. One type of element is an adenylate-and uridylate-rich element (ARE) found in the …
mRNA. One type of element is an adenylate-and uridylate-rich element (ARE) found in the …
Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function
CY Chen, TM Chen, AB Shyu - Molecular and Cellular Biology, 1994 - Am Soc Microbiol
AU-rich elements (ARE) in the 3′ untranslated region of many highly labile mRNAs for
proto-oncogenes, lymphokines, and cytokines can act as an RNA-destabilizing element. The …
proto-oncogenes, lymphokines, and cytokines can act as an RNA-destabilizing element. The …
mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation …
CYA Chen, N Xu, AB Shyu - Molecular and cellular biology, 1995 - Taylor & Francis
Poly (A) tail removal is a critical first step in the decay pathway for many yeast and
mammalian mRNAs. Poly (A) shortening rates can be regulated by cis-acting sequences …
mammalian mRNAs. Poly (A) shortening rates can be regulated by cis-acting sequences …
The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation
AM Zubiaga, JG Belasco… - Molecular and cellular …, 1995 - Am Soc Microbiol
Labile mRNAs that encode cytokine and immediate-early gene products often contain AU-
rich sequences within their 3′ untranslated region (UTR). These AU-rich sequences …
rich sequences within their 3′ untranslated region (UTR). These AU-rich sequences …
U-Rich Sequence-Binding Proteins (URBPs) Interacting with a 20-Nucleotide U-Rich Sequence in the 3′ Untranslated Region of c-fos mRNA May Be Involved in the First Step …
Y You, CYA Chen, AB Shyu - Molecular and cellular biology, 1992 - Taylor & Francis
Rapid decay of the c-fos transcript plays a critical role in controlling transforming potential of
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …
AUUUA is not sufficient to promote poly (A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA (U/A)(U/A)
CA Lagnado, CY Brown, GJ Goodall - Molecular and cellular …, 1994 - Am Soc Microbiol
AU-rich elements (AREs) in the 3′ untranslated regions of several cytokine and oncogene
mRNAs have been shown to function as signals for rapid mRNA degradation, and it is …
mRNAs have been shown to function as signals for rapid mRNA degradation, and it is …
Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements
SSY Peng, CYA Chen, AB Shyu - Molecular and cellular biology, 1996 - Am Soc Microbiol
AU-rich RNA-destabilizing elements (AREs) found in the 3′ untranslated regions of many
labile mRNAs encoding proto-oncoproteins and cytokines generally contain (i) one or more …
labile mRNAs encoding proto-oncoproteins and cytokines generally contain (i) one or more …
Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5′ to the ARE
AM Curatola, MS Nadal… - Molecular and cellular …, 1995 - Taylor & Francis
The 3′ noncoding region (NCR) AU-rich element (ARE) selectively confers rapid
degradation on many mRNAs via a process requiring translation of the message. The role of …
degradation on many mRNAs via a process requiring translation of the message. The role of …
Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elements
G Stoecklin, P Stoeckle, M Lu, O Muehlemann… - Rna, 2001 - cambridge.org
To functionally classify AU-rich elements (AREs) from six different cytokine mRNAs, we
made use of two previously described HT1080-derived cellular mutants (slowA, slowC) that …
made use of two previously described HT1080-derived cellular mutants (slowA, slowC) that …
A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy
N Xu, P Loflin, CYA Chen, AB Shyu - Nucleic acids research, 1998 - academic.oup.com
The widespread occurrence of AU-rich elements (AREs) in mRNAs encoding proteins with
diversified functions and synthesized under a vast variety of physiological conditions …
diversified functions and synthesized under a vast variety of physiological conditions …