Fertilization failure during assisted reproductive technologies (ART) is often unpredictable,
as this failure is encountered only after in vitro fertilization (IVF) and intracytoplasmic sperm …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

Total fertilization failure (TFF), which refers to fertilization failure in all mature oocytes,
accounting for 5%–10% of in vitro fertilization (IVF) cycles and 1%–3% of intracytoplasmic …

Early embryonic arrest is one of the causes of assist reproduction technology (ART) failure.
We have previously reported that the first sperm-derived genetic factor, ACTL7a mutations …

Total fertilization failure (TFF) can occur during in vitro fertilization (IVF) treatments, even
following intracytoplasmic sperm injection (ICSI). Various male or female factors could …

Objective Fertilization is a key event in human reproduction. The male genetic factors
associated with total fertilization failure (TFF) are largely unknown. To date, only mutations in …

Infertility is a frequently diagnosed medical condition affecting over 15% of couples
worldwide (1–3). It has diverse causes, including genetic and environmental factors (4, 5) …

Objective The genetic reasons of total fertilization failure (TFF), especially regarding
suspected oocyte-related factors, are largely unknown. Only PLCZ1, TLE6 and WEE2 …

Background Fertilization failure (FF) is a complex reproductive disorder characterized by the
failure of pronuclei formation during fertilization. In addition to some cases caused by …

Objective To report a unique case of total fertilization failure (TFF) after in vitro fertilization
with intracytoplasmic sperm injection related to homozygous WEE2 gene mutation and …