In this paper we present cellular senescence as the ultimate driver of the aging process, as a
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …

In contrast to the programmed nature of development, it is still a matter of debate whether
aging is an adaptive and regulated process, or merely a consequence arising from a …

Cellular senescence is implicated in a wide range of physiological and pathological
conditions throughout an organism's entire lifetime. In particular, it has become evident that …

Population aging simultaneously highlights the remarkable advances in science, medicine,
and public policy, and the formidable challenges facing society. Indeed, aging is the primary …

Cellular senescence causes ageing | Nature Reviews Molecular Cell Biology Skip to main
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Nearly 50 years have elapsed since Hayflick challenged the dogma that individual human
cells were immortal by demonstrating that after a predictable number of cellular divisions …

The accumulation of 'senescent'cells has long been proposed to act as an ageing
mechanism. These cells display a radically altered transcriptome and degenerative …

Aging in complex multi-cellular organisms such as mammals entails distinctive changes in
cells and molecules that ultimately compromise the fitness of adult organisms. These cellular …

In response to progressive telomere shortening in successive cell divisions, normal somatic
cells enter senescence, during which they cease to proliferate irreversibly and undergo …

One of the most striking findings in biogerontology in the 2010s was the demonstration that
elimination of senescent cells delays many late-life diseases and extends lifespan in mice …