Background Data from randomized trials are lacking on the benefits and risks of initiating
antiretroviral therapy in patients with asymptomatic human immunodeficiency virus (HIV) …

Background The optimal time for the initiation of antiretroviral therapy for asymptomatic
patients with human immunodeficiency virus (HIV) infection is uncertain. Methods We …

Background For adults with human immunodeficiency virus (HIV) infection who have CD4+
T-cell counts that are greater than 200 and less than 350 per cubic millimeter and who live in …

Background Use of antiretroviral treatment for HIV-1 infection has decreased AIDS-related
morbidity and mortality and prevents sexual transmission of HIV-1. However, the best time to …

Background High rates of patient attrition from care between HIV testing and antiretroviral
therapy (ART) initiation have been documented in sub-Saharan Africa, contributing to …

Objectives To compare the response to highly active antiretroviral therapy (HAART) in
individuals starting HAART at different CD4 cell counts. Design The mean increase in CD4 …

BACKGROUND: The CD4 cell count at which combination antiretroviral therapy should be
started is a central, unresolved issue in the care of HIV-1-infected patients. In the absence of …

Objectives: The objective of this review was to update evidence on when to initiate
antiretroviral therapy (ART) to inform revision of the 2013 WHO guidelines for ART in low …

On the basis of studies with relatively short follow-up, treatment guidelines currently
recommend that highly active antiretroviral therapy (HAART) be initiated in asymptomatic …

Background Clinical trials have demonstrated that immediate initiation of antiretroviral
therapy (ART) reduces AIDS-related morbidity and mortality. We tested the hypothesis that …