Conventional pulmonary function tests are limited in the mechanistic insight that they can
provide by the fact that they can only provide average measures of lung function. For …

The report will focus on studies that illustrate how high resolution computed tomography can
be used to provide new insights into airway and lung function, that cannot be obtained with …

Alterations in the structure of the airways, collectively termed airway remodelling, contribute
to airflow obstruction in a variety of chronic lung diseases. While histology has provided …

Bronchial wall area percent (WA%= 100× wall area/total bronchial cross sectional area) is a
standard computed tomographic (CT) measure of central airway morphology utilized in …

Background: In some patients chronic asthma results in irreversible airflow obstruction. High
resolution computed tomography (HRCT) has been advocated for assessing the structural …

The use of traditional pulmonary function tests (PFT) to assess airflow obstruction is limited
by the fact that these measurements are global and can neither express the potential …

Airway remodeling is an important pathophysiological mechanism in a variety of chronic
airway diseases. Historically investigators have had to use invasive techniques such as …

Airway remodeling is an established feature of asthma. Histologic examination is essential
in the assessment of remodeling that is a pathologic concept. Examinations of autopsied or …

Airway remodeling is extremely important in the pathophysiology of chronic obstructive
pulmonary disease (COPD). Since the site and nature of airflow obstruction was described …

Changes in airway resistance are reported to account for only a portion of changes in total
lung resistance. The fraction of total lung resistance caused by airway resistance is difficult …