Lifelong mammalian male fertility is maintained through an intricate balance between
spermatogonial proliferation and differentiation. DNA damage in spermatogonia, for …

DNA damage response in adult spermatogenic cells should limit the propagation of
mutations to the offspring, without being detrimental to fertility. In differentiating …

Radiation and chemotherapeutic drugs cause permanent sterility in male rats, not by killing
most of the spermatogonial stem cells, but by blocking their differentiation in a testosterone …

Neonatal gonocytes are the precursors of both spermatogonial stem cells and
spermatogonia; thus, any persistant DNA damage in these cells may lead to heritable …

Purpose Testicular spermatogenesis is extremely sensitive to radiation-induced damage,
and even low scattered doses to testis from radiation therapy may pose reproductive risks …

Although gonadotropins and androgen are required for normal spermatogenesis and both
testosterone and follicle-stimulating hormone (FSH) are responsible for the inhibition of …

Background Irradiation or chemotherapy that suspend normal spermatogenesis is
commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can …

The effect of the p53 gene on the survival of mouse testicular cells was evaluated by
analysis of degenerating and terminal transferase-mediated end labeling (TUNEL)-positive …

Germ cells are thought to exhibit a unique DNA damage response that differs from that of
somatic stem cells, and previous studies suggested that Trp53 is not involved in the survival …

Spermatogonial stem cells (SSCs) must maintain the integrity of their genome to prevent
reproduction failure and limit the hereditary risk associated with transmission to the progeny …