Experimental animal models of aquaporin‐4‐IgG‐seropositive neuromyelitis optica spectrum disorders: progress and shortcomings

T Duan, AS Verkman - Brain Pathology, 2020 - Wiley Online Library
Neuromyelitis optica spectrum disorders (NMOSD) is a heterogeneous group of
neuroinflammatory conditions associated with demyelination primarily in spinal cord and …

Neuromyelitis optica spectrum disorder: Pathogenesis, treatment, and experimental models

Y Wu, L Zhong, J Geng - Multiple sclerosis and related disorders, 2019 - Elsevier
Neuromyelitis optica (NMO) and NMO spectrum disorder (NMOSD) are inflammatory CNS
syndromes mainly involving the optic nerve and/or spinal cord and characterized by the …

Experimental models of neuromyelitis optica: current status, challenges and future directions

M Li, Y Yan - Neuroscience bulletin, 2015 - Springer
Neuromyelitis optica (NMO) is a recurrent inflammatory disease that predominantly attacks
the opticnerves and spinal cord. NMO-IgG, the specific autoantibody present in the vast …

Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies

J Ratelade, AS Verkman - The international journal of biochemistry & cell …, 2012 - Elsevier
Neuromyelitis optica (NMO) is an autoimmune 'aquaporinopathy'of the central nervous
system that causes inflammatory demyelinating lesions primarily in spinal cord and optic …

The role of AQP4 in neuromyelitis optica: more answers, more questions

X Yang, BR Ransom, JF Ma - Journal of neuroimmunology, 2016 - Elsevier
Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the
optic nerves and spinal cord. The presence of antibodies to the water channel protein …

Experimental models of neuromyelitis optica

M Bradl, H Lassmann - Brain Pathology, 2014 - Wiley Online Library
For a long time, the most important inflammatory demyelinating diseases of the central
nervous system (CNS), for example, multiple sclerosis (MS) and neuromyelitis optica (NMO) …

Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

S Jarius, D Franciotta, F Paul, K Ruprecht… - Journal of …, 2010 - Springer
Abstract Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with
highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG) …

[PDF][PDF] Neuromyelitis optica spectrum disorders with and without aquaporin 4 antibody: Characterization, differential diagnosis, and recent advances

RJ Baranello, JR Avasarala - J Neuro Ther, 2015 - nobleresearch.org
Importance: The term neuromyelitis optica spectrum disorders (NMOSD) currently includes
neuromyelitis optica (NMO) and rare neurological disorders characterized by specific IgG …

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

S Jarius, B Wildemann - Nature Reviews Neurology, 2010 - nature.com
Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …

Treatment of neuromyelitis optica spectrum disorders

KH Chan, CY Lee - International Journal of Molecular Sciences, 2021 - mdpi.com
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune central nervous system
(CNS) inflammatory disorder that can lead to serious disability and mortality. Females are …