Diabetes mellitus (DM), a chronic metabolic disorder caused by uncontrolled high blood
glucose levels due to insufficient insulin secretion or insulin resistance, is one of the most …

Ferroptosis is recently identified, an iron‐and reactive oxygen species‐(ROS‐) dependent
form of regulated cell death. This study was designed to determine the existence of …

Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in
osteoarthritis patients, which is occasionally accompanied with the serious side effects of …

Bone‑related diseases comprise a large group of common diseases, including fractures,
osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly …

Osteoporosis is widely regarded as one of the typical aging-related diseases due to the
impairment of bone remodeling. The silent information regulator of transcription1 (SIRT1) is …

Many studies have investigated the actions of melatonin on osteoblasts and osteoclasts.
However, the underlying mechanisms, especially regarding osteocyte function, remain …

Osteoporosis development is closely associated with oxidative stress and reactive oxygen
species (ROS). Taurine has potential antioxidant effects, but its role in osteoblasts is not …

Tryptophan, an essential amino acid through a series of enzymatic reactions gives rise to
various metabolites, viz. serotonin and melatonin, that regulate distinct biological functions …

Myocardial ischemia–reperfusion (MI/R) injury is a crucial cause for mortality throughout the
world. Recent studies indicated that melatonin might exert profound cardio-protective effect …

Microgravity can inhibit osteoblast proliferation and promote apoptosis, which is related to a
reduction in mechanical stress on the bones and results in disuse osteoporosis, but the …