In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

Epigenetic gene silencing is a hallmark of cancer cells. Two important types of epigenetic
changes are DNA methylation and histone modification. These modifications are catalysed …

The fundamental role of altered epigenetic modification patterns in tumorigenesis
establishes epigenetic regulatory enzymes as important targets for cancer therapy. Over the …

Epigenetic changes are defined as inherited modifications that are not present in DNA
sequence. Gene expression is regulated at various levels and not only in response to DNA …

Over the past few years several drugs that target epigenetic modifications have shown
clinical benefits, thus seemingly validating epigenetic cancer therapy. More recently …

Abnormalities in the epigenetic regulation of chromatin structure and function can lead to
aberrant gene expression and cancer development. Consequently, epigenetic therapies aim …

The past decades have brought major breakthroughs in the identification of distinct genetic
alterations (eg, mutations, chromosomal aberrations) in various human tumors, leading to …

In the last three decades huge efforts have been made to characterize genetic defects
responsible for cancer development and progression, leading to the comprehensive …

Abstract 'Epigenetics' is defined as the inheritable changes in gene expression with no
alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of …

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …