Thirteen years ago, Véniant et al1 made the intriguing observation that targeted expression
of rat prorenin to the liver under the control of the human α1-antitrypsin promoter increased …

In addition to its well-known role in regulating blood pressure and fluid balance, the renin-
angiotensin-aldosterone system (RAAS) has continued to fascinate both researchers and …

The recognition of two new components of the renin–angiotensin system (RAS), the (pro)
renin receptor [1] and a new class of RAS blockers, the renin inhibitors [2, 3], has propelled …

Prorenin, the precursor of renin, has for a long time been considered to be functionally inert,
despite high circulating concentrations. Plasma levels of prorenin usually exceed renin …

Elevated circulating levels of prorenin, the protein precursor of renin, have been reported to
precede the appearance of microvascular complications in diabetes. While prorenin is …

Elevated levels of circulating prorenin, the precursor of renin, have been reported to precede
the appearance of microvascular complications in diabetes mellitus. Although several …

Several articles have appeared recently on the role of tissue prorenin in the pathogenesis of
cardiovascular and renal damage in experimental models of hypertension and diabetes …

A great deal of attention has been focused on the receptorassociated prorenin system
triggered by binding of prorenin to the prorenin receptor. 1 Recent studies have …

Mercure et al1 reported the targeted expression of mouse prorenin to the liver of mice. Liver
expression of mouse prorenin was under the control of the transthyretin gene promoter, and …

Background: The function of prorenin, the inactive precursor of renin, remains unclear after
many decades of research. The discovery of a (pro) renin receptor suggested that prorenin …