Mitochondrial therapeutic interventions in Alzheimer's disease
Alzheimer's Disease (AD) is one of the most common age-related neurodegenerative
diseases in the developed world. Treatment of AD is particularly challenging as the drug …
diseases in the developed world. Treatment of AD is particularly challenging as the drug …
The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?
Mitochondria are the power engine generating biochemical energy in the cell. Mitochondrial
dysfunction and bioenergy deficiency is closely linked to the pathogenesis of …
dysfunction and bioenergy deficiency is closely linked to the pathogenesis of …
Current advances in mitochondrial targeted interventions in Alzheimer's disease
T Sousa, PI Moreira, S Cardoso - Biomedicines, 2023 - mdpi.com
Alzheimer's disease is the most prevalent neurodegenerative disorder and affects the lives
not only of those who are diagnosed but also of their caregivers. Despite the enormous …
not only of those who are diagnosed but also of their caregivers. Despite the enormous …
Mitochondria as a target for neuroprotection: implications for Alzheimer s disease
S Cardoso, RM Seiça, PI Moreira - Expert review of …, 2017 - Taylor & Francis
Introduction: Alzheimer's disease (AD), the most common form of dementia, is marked by
progressive loss of memory and impairment of cognitive ability. Despite decades of intensive …
progressive loss of memory and impairment of cognitive ability. Despite decades of intensive …
Mitochondria as potential targets in Alzheimer disease therapy: an update
G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …
affects mostly the elderly population. At the moment, no effective treatments are available in …
Mitochondrial dysfunction: different routes to Alzheimer's disease therapy
Mitochondria are dynamic ATP‐generating organelle which contribute to many cellular
functions including bioenergetics processes, intracellular calcium regulation, alteration of …
functions including bioenergetics processes, intracellular calcium regulation, alteration of …
Targeting mitochondria in Alzheimer disease: rationale and perspectives
A decline in mitochondrial function plays a key role in the aging process and increases the
incidence of age-related disorders, including Alzheimer disease (AD). Mitochondria—the …
incidence of age-related disorders, including Alzheimer disease (AD). Mitochondria—the …
[HTML][HTML] Mitochondrial dysfunction in Alzheimer's disease and the rationale for bioenergetics based therapies
IG Onyango, J Dennis, SM Khan - Aging and disease, 2016 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the
progressive loss of cholinergic neurons, leading to the onset of severe behavioral, motor …
progressive loss of cholinergic neurons, leading to the onset of severe behavioral, motor …
Mitochondrial dysfunction in Alzheimer's disease and progress in mitochondria-targeted therapeutics
PJ Flannery, E Trushina - Current Behavioral Neuroscience Reports, 2019 - Springer
Abstract Purpose of Review Mitochondria are essential for facilitating energy homeostasis
under ever-changing environmental conditions. Mitochondrial dysfunction has been …
under ever-changing environmental conditions. Mitochondrial dysfunction has been …
[HTML][HTML] Mitochondrial dysfunction and Alzheimer's disease: prospects for therapeutic intervention
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease and has become a
major socioeconomic issue in many developed countries. Currently available therapeutic …
major socioeconomic issue in many developed countries. Currently available therapeutic …