Apoptosis is an important mechanism during the immunopathogenesis of sepsis. Early
programmed cell death of lymphocytes substantially impairs innate and adaptive immunity …

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …

Over time it has become clear that, much like other organ systems, the function and
responsiveness of the immune system is impaired during the course of sepsis and that this is …

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
response to infection that leads to uncontrolled inflammatory response followed by …

Treatment of sepsis and septic shock remains a clinical conundrum. Recent prospective
trials with anti-cytokine and anti-inflammatory therapies have shown only modest clinical …

Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …

Sepsis with subsequent multiple-organ dysfunction is a distinct systemic inflammatory
response to concealed or obvious infection, and it is a leading cause of death in intensive …

Although the prevailing concept has been that mortality in sepsis results from an unbridled
hyper-inflammatory cytokine-mediated response, the failure of more than 30 clinical trials to …

Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …

The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …